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A greater issue than soil depletion is the loss of phytonutrients through selective breeding for taste and early picking of produce for ease of transportation. A fantastic book on this subject, with advice for how to find produce with higher phytonutrient content, is Eating on the Wild Side[0].

[0] https://www.amazon.com/Eating-Wild-Side-Missing-Optimum/dp/0...

View this Book on Amazon