If you are interested in this, you might also be interested in "promoter genes" which tend to be destructive to the organism they are part of, but which are also very good at promoting themselves, so they survive in the genome despite being harmful. A good book on the subject:

Genes in Conflict: The Biology of Selfish Genetic Elements

https://www.amazon.com/Genes-Conflict-Biology-Selfish-Elemen...