Here you go:

http://www.amazon.com/Systems-Graphic-Systeme-Visuele-Gestal...

Books are designed. Lots of consideration is put into the typography, layout, rhythm and form of printed books, and those design choices stretch back over a hundred years. There is much more at play than "justification, and paragraphs, and if you're lucky a nice font."

https://en.wikipedia.org/wiki/Jan_Tschichold

http://www.amazon.com/Systems-Graphic-Systeme-Visuele-Gestal...

https://en.wikipedia.org/wiki/The_Elements_of_Typographic_St...

You use grids to group and align your content.

Basically you need look at your design in order to determine what would make most sense.

A very popular choice is to divide it into three equal sizes and then have one of them be the right or left column, while the two others combine to form the other column.

So you end up with two columns one for content and one for navigation (typical blog look)

Grids can obviously also be much more complicated as those used in photoshop, 3dmax, word or windows/osx.

If you want to get really into grids I can recommend probably the best book written about them.

Josef Muller Brockman Grid Systems

http://www.amazon.com/Systems-Graphic-Systeme-Visuele-Gestal...

I've been inspired by stuff from Josef Muller-Brockmann. I'm not a graphic artist, but I'm getting this book when I get a chance: http://www.amazon.com/Systems-Graphic-Systeme-Visuele-Gestal...