Found in 5 comments on Hacker News
jseliger · 2016-05-29 · Original thread
Given the way the current drug development system has been designed it is very hard to bring a new antibiotic to market

It's hard to get any drug to market, and the FDA's intransigence is tragic. Alex Tabarrok has a good book on this called Launching The Innovation Renaissance: A New Path to Bring Smart Ideas to Market Fast (https://www.amazon.com/Launching-Innovation-Renaissance-Brin...).

jseliger · 2016-01-21 · Original thread
and this model does not go down well with the American electorate, generally speaking.

Actually, the U.S. government already spends about 41% of GDP: https://en.wikipedia.org/wiki/Government_spending#As_a_perce..., and that's roughly comparable with some European countries. So taxes are already extremely high.

At least on the federal level, about a quarter is spent on Social Security (income transfer), another quarter is spent on healthcare (mostly Medicare, with some Medicaid) and another fifth goes to defense / warfare: https://en.wikipedia.org/wiki/United_States_federal_budget.

U.S. tax mostly goes to transfer payments and defense / warfare. Whether that is a good thing is debatable; personally, I'd like to see more innovation and less warfare/welfare (http://www.amazon.com/Launching-Innovation-Renaissance-Bring...), but by pretty much any reasonable standard the U.S. already pays lots of tax.

jseliger · 2014-12-01 · Original thread
AT&T couldn't even roll out U-Verse in San Francisco: http://www.fiercetelecom.com/story/att-ordered-stop-u-verse-... , and it's among the hardest cities in the U.S. to build any physical infracture: http://www.citylab.com/housing/2013/10/san-francisco-exodus/... . As demand for housing the bay area rises supply remains constant, leading to dramatic price increases.

These are political problems and they have political solutions. It's not "sad" that Silicon Valley can't get faster Internet access; it's the nature of the way California's politics as a whole have developed. The number of veto players (http://www.amazon.com/Launching-Innovation-Renaissance-Bring...) and NIMBYs ensure the problems California is currently experiencing.

jseliger · 2014-02-11 · Original thread
"Fail fast, fail often" is less of a good thing when it's actual people's lives.

It depends. A lot of people are already losing their lives through inaction.

This is slightly tangential, Alex Tabarrok's book Launching the Innovation Renaissance is good on the subject of FDA inertia and spending too much time trying to prove efficacy and too little emphasis on experimentation and rapid iteration: http://www.amazon.com/Launching-Innovation-Renaissance-Marke... .

jseliger · 2013-11-15 · Original thread
This is one of the more astute comments in this thread, and I hope it gets the upvotes it deserves. Alex Tabarrok also discusses the "veto player" problem some in Launching the Innovation Renaissance (http://www.amazon.com/Launching-Innovation-Renaissance-Marke...), which is worth reading if you're interested in these issues.

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