Found in 12 comments on Hacker News
Balgair · 2024-06-12 · Original thread
Thanks!

I did a career change from particle physics to bioengineering and neuroscience ( and now AI/ML for EE applications with bioreactors, but that's another story).

There's not a lot of recent texts really. US based academia in the last few years has been really bad, as the replication crisis turned into a dry cough; I.E. make up data all you want, no one will care.

So, I'd go back to the classics like Kandel ( https://www.amazon.com/Principles-Neural-Science-Fifth-Kande...) for the neuro side. Bioengineering really doesn't have any canonical texts yet as the field is do disparate and new still. For the only bio side, really any used text book will do, as the basics are really wide spread at this point. You can dig into good text books here: https://www.lesswrong.com/posts/xg3hXCYQPJkwHyik2/the-best-t...

I'd really recommend reading Darwin though. Going way back to the literal foundation really helps set the stage, mentally, and bring you back to what is really going on with relation to the wider human condition.

Just about any review article more than 10 years old is also going to be pretty good. I'd stay way from review articles less than 5 years old though, as things change and retractions come out.

I'll warn you though, the concepts and mental models that you've built up on the Engineering side are not really going to help you with the bio side. Yes, the study habits will help. But bio is really really complicated. You can't abstract the cow into a meter sphere of water. In bio, you really do care about that cell on the medial side of the fourth mesenchymal layer of the second stomach of the cow. You are going to have to get comfortable memorizing pathways and strange names for a few years before all the pieces will even start fitting together. Again, bio is something that's been surviving, ripping, and gouging, for ~4 billion years. She don't have time to stop and let us know what is up.

Balgair · 2023-11-29 · Original thread
Neuroscientist here:

1. Grad school. I came in as a more tech/physics applicant and had to learn it all from a fire hose.

The canonical book is Kandell: https://www.amazon.com/Principles-Neural-Science-Fifth-Kande...

But, please, don;t read that unless you're a neuroscientist. It's too much for a 'layperson'

This one should be better for most casual people with an interest: https://www.amazon.com/Creating-Mind-How-Brain-Works/dp/0393...

Honestly? Just ask chatGPT questions that you have. It's more than good enough for casual interest.

2. Nope. Not even as a person researching and doing experiments. Most US based academia is firmly in the camp of 'beatings will continue until morale improves'. They ignore almost all of their own findings about the need for sleep and learning and spaced repetition when it comes to teaching. Culture is hard to overcome.

Nearly everything I've learned about optimal brain performance (if you can even consider that a thing, which I do not), I learned from reading papers (mostly reviews) and random internet garbage that somehow ended up being true.

Balgair · 2019-07-01 · Original thread
> if you took the optic nerve and attached it to another part of the neocortex, that part would become the visual region.

FYI, that is super hand-wavey and covers over a lot about how the path of the information from the cones/rods gets into V1. The chain of neurons that pass infomation from your eyes to V1 is well studied [0]. Interruptions in that path cause a lot of sightedness issues and are not fun diseases to have. The musician, Stevie Wonder, among others, aledgedly has a form of blindness known as blindsight [1] where relfexes to motion are perserved, but information is not passed into the conscious mind.

In the end, though neuroscience is a facinating subject, we're just in the beginning of our understanding of the brain. More research is needed.

[0] https://en.wikipedia.org/wiki/Optic_chiasm a good place to start learning about the chain of information transfer.

[1] https://en.wikipedia.org/wiki/Blindsight

EDIT: Additionally, if you want to learn more about neuroscience, the best place to look is at Kandel's Principals of Neural Science [2]. It is a tome of a book, but is the best place to get a deep dive into the brain and our understanding of it. I've not yet seen anything else that is somewhat accessible to the general public but also gets into all the issues with any particular experiment. Most pop-sci book brush over a lot of the very important and thorny issues that each experiment has. I'd also love to know of a good book that is more accessible than Kandel.

[2] https://www.amazon.com/Principles-Neural-Science-Fifth-Kande...

Balgair · 2018-10-01 · Original thread
In neuroscience:

Principles of Neural Science, Fifth Edition (Principles of Neural Science (Kandel)) 5th Edition

https://www.amazon.com/Principles-Neural-Science-Fifth-Kande...

idrios · 2018-03-16 · Original thread
Also relevant, though maybe deviating a bit from engineering: Principles of Neural Science by Kandel and Schwartz https://www.amazon.com/Principles-Neural-Science-Fifth-Kande...
dqpb · 2018-03-14 · Original thread
>It's what the majority of the world believes

This has never been a good proxy for truth. It is also completely irrelevant given that the majority of the world has never studied neuroscience.

>science has no idea what consciousness is

Not true. Neuroscience has discovered a lot about consciousness. I recommend Principles of Neural Science if you're interested: https://www.amazon.com/Principles-Neural-Science-Fifth-Kande...

>Plus, there are all kinds of problems and contradictions if the mind reduces to matter.

Such as?

Balgair · 2017-11-02 · Original thread
https://www.amazon.com/Principles-Neural-Science-Fifth-Kande...

This is a good text, at an upper-div/grad level, of fundamental neuroscience with all sources cited.

That particular connection is straightforward to do in humans. A Golgi stain to the rector muscles/ON and dissection in cadavers would be sufficient to trace the reflex to the SC and then another Golgi stain to that area to get back to the optic nerve. I'm unfamiliar with the toxicity of Golgi stains, but it may be able to be done alive.

Also, the visual systems to the brain-stem are remarkably conserved through evolution. I would not be surprised to see this connection in lampreys. That any significant percent of humans lack it would be a hell of paper.

Blind individuals usually have these reflexes too (like Stevie Wonder): https://en.wikipedia.org/wiki/Blindsight

Balgair · 2017-03-23 · Original thread
Yes, 'taste' is incredibly complicated and there are many elements to it, from texture, to smell, to temperature, to emotional state, to blood pressure, etc. We are still discovering what tastes humans actually possess and where they possess them in their bodies. What you are classifying as 'taste' is many things other than the definition of taste; you include smell and texture in the lists above. Especially on the bitter part, human sensation of bitter is highly variable from person to person. What you may consider bitter may not be able to be sensed by your customers and what you cannot sense may be tasted by your customers, hence why many confectioners tend towards a similar mean taste profile (pepsi/coke). You mention that things may 'taste like wood', this is a cultural association that you may want to be aware of. Try getting other people from other cultures/environments to drink your stuff and see if they also report these sensations. As far as 'drying out your mouth', this is again highly variable depending on hydration, humidity, personal preference, etc. For example, a friend of mine loves seltzer water for 'the burn', while I hate it for the exact same reason. I also drink my coffee black these days, but I will change my taste from time to time. Mostly I am just addicted to caffeine and coffee is the cheapest way to get the fix.

For more information on the sensation of taste and all it's myriad complexities, you may want to check out these resources:

http://www.ucdenver.edu/academics/colleges/medicalschool/dep... Sue is a world expert on taste, along with Tom Finger, and her work is excellent in every way.

https://www.amazon.com/Principles-Neural-Science-Fifth-Kande... The bible of neural sciences, though thick and dense, the sections on gustation and olfaction may prove useful to your endeavors.

Edit: Here are some other resources on how to modify your taste sensation to better understand how your taste buds work:

https://en.wikipedia.org/wiki/Category:Taste_modifiers

There is also a supplement that you can take that will elliminate your sensation of sweet for a few hours, but I forget the name

Lastly, to understand umami, try getting a few bags of chips of similar salt content and hold your nose the entire time. One of just regular Lays potato chips, one of something like Doritos, and one of those baked Parmesan cheese ships from whole foods. While eating them with your nose held close, try to recognize the changes in the umami taste.

Balgair · 2015-03-05 · Original thread
Please pick up a neuroscience textbook such as this one : http://www.amazon.com/Principles-Neural-Science-Edition-Kand... (here is the camel camel camel page for price comparison: http://camelcamelcamel.com/Principles-Neural-Science-Edition... )

Much of what you say is correct on the first pass, and is better than that of the typical citizen, however, some important details are missing. It seems like you are actually interested in the subject and would benefit from learning in depth about the subjects.

The mind does indeed work in parallel, but you cannot focus on 2 things at once. I think you are referring to reflexes, which are subtlety different than cerebellar functioning and 'automatic' movements. You are very much in control of your own mind, how else would you define what a mind is? However, you are correct in thinking that certain neural processes are outside of our control and that our mind is conditioned by experience to perceive things in a schema.

Really though, the book I linked is great for you, as it seems you have an interest in the subject and want to learn more.

jdale27 · 2013-07-08 · Original thread
If you really want to learn neuroscience, here's the book: http://www.amazon.com/Principles-Neural-Science-Edition-eboo...

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