I wrote also a book about the state of ALS research (updated on February 1) 
I would be interested in exploring the idea of using Cell Penetrating Peptides (or PROTAC) to either relocate or remove entirely TDP-43 aggregates. It could be studied at low cost on Ciona (an aquarium animal that looks like a plant). If someone is interested my email address is in my profile.
Ciona intestinalis has motor neurons and can even regenerate its entire nervous system in only one month!
I self-published a book on ALS (the disease) research . I wonder if this would be enough to be accepted as a PhD student.
Fresh book recommendations delivered straight to your inbox every Thursday.