I’m really worried about the subset of the population with preexisting mental disorders such as manic depressive disorder, schizophrenia, and depression who will suffer a psychotic break from the use of these substances. Maybe I’m wrong, but from what I’ve heard and read it seems like there’s no way to know what will happen until you try it. A certain percentage of the population goes to hell in the most literal sense of the word possible. Anecdotally, the people I personally know who have tried psychedelics (maybe 6 or 7 people, all who did no know one another) seem to have a weird mental frailty to them, where because their ego disappeared(?) briefly and psychedelics were allowing mental connections that wouldn’t have arisen without psychedelics, they begin to question everything, almost like a rebuilding of their fundamental axioms from scratch. There’s also a strange fervor for others to try it, even from people who have had bad trips.

Joe Rogan had Michael Pollan on recently[0], who wrote The Omnivores Dilemma and a new book How To Change Your Mind[1] which talks about the benefits of hallucinogens. They also briefly talk about the psychotic breaks some people will experience as a result of widespread use and shrug it off like it’ll be fine. Aldous Huxley wrote a book about his use of mescaline called Doors of Perception[2] which felt almost unintelligible and very strange to me as a person who has not (and will not, as my mental health is great but I’m certain I’m at risk of a psychotic break from hallucinogens due to family history) done psychedelics.

[0] https://m.youtube.com/watch?v=tz4CrWE_P0g

[1] https://www.amazon.com/Change-Your-Mind-Consciousness-Transc...

[2] https://www.amazon.com/Doors-Perception-Heaven-Hell/dp/00617...